RGLS4326 [2229964-07-0]

TargetMol Chemicals

RGLS4326 [2229964-07-0]

999

2229964-07-0

Research Use Only

RGLS4326

C95H115F3N32O51P8S8

3082.4

RGLS4326 (RG4326) is a short oligonucleotide inhibitor of microRNA-17 (miR-17), with a pioneering role in its class. This compound, with a research focus on autosomal dominant polycystic kidney disease (ADPKD), effectively suppresses the activity of miR-17 in HeLa cells, displaying an EC50 value of 28.3 nM.

3 years

[H][C@]12O[C@@H](C)[C@](COP(S)(=O)O[C@H]3[C@@]4([H])O[C@@H](C)[C@]3(COP(S)(=O)O[C@@H]3[C@@H](COP(S)(=O)O[C@@H]5[C@@H](COP(S)(=O)O[C@@H]6[C@@H](COP(S)(=O)O[C@@H]7[C@@H](COP(S)(=O)O[C@@H]8[C@@H](COP(S)(=O)O[C@H]9[C@@]%10([H])O[C@@H](C)[C@]9(COP(S)(=O)O[C@H]9[C@@]%11([H])O[C@@H](C)[C@]9(CO)O[C@H]%11n9cnc%11c(N)ncnc9%11)O[C@H]%10n9cnc%10c9[nH]c(N)nc%10=O)O[C@H]([C@@H]8OC)n8ccc(N)nc8=O)O[C@H]([C@@H]7F)n7cnc8c(N)ncnc78)O[C@H]([C@@H]6F)n6ccc(N)nc6=O)O[C@H]([C@@H]5F)n5ccc(=O)[nH]c5=O)O[C@H]([C@@H]3OC)n3ccc(=O)[nH]c3=O)O[C@H]4n3ccc(=O)[nH]c3=O)(O[C@H]1n1cnc3c1[nH]c(N)nc3=O)[C@H]2O - TLB:89:88:78:81.82,4:3:186.187:199,178:177:12:15.16,101:100:65:68.69,THB:83:82:78:87.88,188:187:199:2.3,17:16:12:177.176,70:69:65:100.99 -

-20°C

12352200