RH12

MedChem Express

RH12

5

Research Use Only

C20H19N3O4

365.38

RH12 is a dual inhibitor for SARS-CoV-2 related RNA-dependent RNA polymerase (RdRp, IC50 is 4.42 nM) and human transmembrane serine protease 2 (TMPRSS2, IC50 is 4.2 nM). RH12 exhibits antiviral efficacy. RH12 inhibits viral replication and absorption, and exhibits a 90.5% virucidal effects on Vero-E6 cells. RH12 inhibits cell viability of Calu-3 with an IC50 of 17.5 nM[1].

N=C(N)NC1=CC=C(C(OC2=CC=C(OC(C=C3C(C)C)=O)C3=C2)=O)C=C1

12352200