RHOB Antibody

Cusabio

RHOB Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

RHOB

ras homolog family member B

ARH6, ARHB, MST081, MSTP081, RHOH6, rho-related GTP-binding protein RhoB, Aplysia RAS-related homolog 6, h6, oncogene RHO H6, ras homolog gene family, member B, rho cDNA clone 6

Rabbit

IgG

Rho-related GTP-binding protein RhoB

Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells. Chardin P., Nucleic Acids Res. 16:2717-2717(1988). Puhl H.L. III, Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. Halleck A., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

Human

-20°C or -80°C

41116161