RIC8A Polyclonal Antibody

Reddot Biotech

RIC8A Polyclonal Antibody

5

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.96 mg/ml

Unconjugated

RIC8A

RIC8 guanine nucleotide exchange factor A

resistance to inhibitors of cholinesterase 8 homolog A; RIC8; synembryn-A

Rabbit

IgG

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Human, Mouse, Rat

-20°C

12352203