RIF1 (N) Antibody, Rabbit Polyclonal

Biorbyt

RIF1 antibody

16

WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications.Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human RIF1.

Western Blot

WB:1:1000-1:3000 WB

Research Use Only

Polyclonal

100 ug/ml

Unconjugated

RIF1

replication timing regulatory factor 1

RAP1 interacting factor homolog; rap1-interacting factor 1 homolog; telomere-associated protein RIF1

Rabbit

Telomere-associated protein RIF1

Rabbit polyclonal to RIF1. Telomere-associated protein RIF1 shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. RIF1 localizes to aberrant telomeres and may be involved in DNA repair. RIF1 is required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both pathways. RIF1 seems to play no role in either the G1/S or G2/M DNA damage checkpoints.

Human

-20°C

12352203