Rigosertib (sodium) [592542-60-4]

MedChem Express

Rigosertib (sodium) [592542-60-4]

10

592542-60-4

Research Use Only

99.57

C21H24NNaO8S

473.47

Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle[1][2]. Rigosertib sodium is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM[3].

COC1=CC=C(C=C1NCC(O[Na])=O)CS(/C=C/C2=C(C=C(C=C2OC)OC)OC)(=O)=O

2°C to 8°C

12352200