RK-20448 [479501-40-1]

MedChem Express

RK-20448 [479501-40-1]

5

479501-40-1

Research Use Only

99.38

C29H34N6O

482.62

RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R and Tie-2 with IC50 values of 0.24, 1.19, 10.74 and 5.85 microM, respectively. RK-20448 also inhibits BLK, Csk, Fyn and Lyn with IC50 values of 0.37, 4.27, 2.03 and 0.43 microM, respectively. RK-20448 is the cis isomer of A-419259 (HY-15764)[1][2].

NC1=C(C2=NC=N1)C(C3=CC=C(C=C3)OC4=CC=CC=C4)=CN2[C@H]5CC[C@H](CC5)N6CCN(CC6)C

-20°C,2°C to 8°C

12352200