RMC-7977

AbMole BioScience

RMC-7977

9

2765082-12-8

Chemical

Research Use Only

C47H60N8O6S

865.09

RMC-7977 is a highly selective, reversible, tri-complex RAS inhibitor of the active (GTP-bound) forms of KRAS, HRAS, and NRAS, with affinity for both mutant and wild type (WT) variants. RMC-7977 demonstrated potent activity against RAS-addicted tumours carrying various RAS genotypes, particularly against cancer models with KRAS codon 12 mutations (KRASG12X).

12352200