RNA polymerase II-IN-2

MedChem Express

RNA polymerase II-IN-2 [2891451-33-3]

10

Research Use Only

C41H58N10O12S

915.02

RNA polymerase II-IN-2 (compound 20iii) is a potent RNA polymerase II (Pol II) inhibitor with Ki value of 9.5 nM. RNA polymerase II-IN-2 has cytotoxicity against cancer cells, and exhibits 2 and 5 fold toxicity than alpha-amanitin against CHO and HEK293[1].

O=C([C@H](C(CC)CC)NC(CNC1=O)=O)NCC(N[C@@H]2C(N[C@H](C(N3C[C@@H](C[C@H]3C(N[C@H](C(N[C@H]1CC4=C(S[C@H]2C)NC5=C4C=CC=C5)=O)[C@H]([C@H](CO)O)C)=O)O)=O)CC(N)=O)=O)=O

12131703