RNASEL Antibody

Cusabio

RNASEL Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

RNASEL

ribonuclease L

PRCA1, RNS4, 2-5A-dependent ribonuclease, 2',5'-oligoisoadenylate synthetase-dependent, 2-5A-dependent RNase, RNase L, interferon-induced 2-5A-dependent RNase, ribonuclease 4

Rabbit

IgG

2-5A-dependent ribonuclease

Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.

Human

-20°C or -80°C

41116161