RNF20 Antibody

Cusabio

RNF20 Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

RNF20

ring finger protein 20

BRE1, BRE1A, hBRE1, E3 ubiquitin-protein ligase BRE1A, BRE1 E3 ubiquitin ligase homolog, RING-type E3 ubiquitin transferase BRE1A, homolog of S. cerevisiae BRE1

Rabbit

IgG

E3 ubiquitin-protein ligase BRE1A

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of Lys-120 of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.

Human

-20°C or -80°C

41116161