RNF34 Antibody

Cusabio

RNF34 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

RNF34

ring finger protein 34

CARP-1, CARP1, RFI, RIF, RIFF, hRFI, E3 ubiquitin-protein ligase RNF34, FYVE-RING finger protein MOMO, RING finger protein RIFF, RING-type E3 ubiquitin transferase RNF34, caspase regulator CARP1, caspases-8 and -10-associated RING finger protein 1, human RING finger homologous to inhibitor of apoptosis protein, ring finger protein 34, E3 ubiquitin protein ligase

Rabbit

IgG

E3 ubiquitin-protein ligase RNF34

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate Lys-48-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through Lys-48-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219).

Human

-20°C or -80°C

41116161