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RNPS1 antibody

GTX129789
GeneTex
ApplicationsWestern Blot
Product group Antibodies
TargetRNPS1
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Overview

  • Supplier
    GeneTex
  • Product Name
    RNPS1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID10921
  • Target name
    RNPS1
  • Target description
    RNA binding protein with serine rich domain 1
  • Target synonyms
    E5.1, RNA-binding protein with serine-rich domain 1, RNA binding protein with serine-rich domain, RNA-binding protein S1, serine-rich domain, SR protein, SR-related protein LDC2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ15287
  • Protein Name
    RNA-binding protein with serine-rich domain 1
  • Scientific Description
    This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Zhong X, Choi JH, Hildebrand S, et al. RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice. Proc Natl Acad Sci U S A. 2022,119(18):e2200128119. doi: 10.1073/pnas.2200128119
    Read this paper
  • Hou S, Qu D, Li Y, et al. XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence. Nucleic Acids Res. 2019,47(15):8239-8254. doi: 10.1093/nar/gkz532
    Read this paper
  • Zhang H, Mahadevan K, Palazzo AF. Sumoylation is Required for the Cytoplasmic Accumulation of a Subset of mRNAs. Genes (Basel). 2014,5(4):982-1000. doi: 10.3390/genes5040982
    Read this paper