Ro 67-4853

MedChem Express

Ro 67-4853 [302841-89-0]

10

302841-89-0

Research Use Only

99.90

C19H19NO4

325.36

Ro 67-4853 is a positive allosteric modulator (PAM) of mGluR1 ( pEC 50 =7.16 for rmGlu1a receptor). Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain (TMD) of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation [1] [2] [3] [4] .

CCCCOC(NC(C1C2=CC=CC=C2OC3=CC=CC=C13)=O)=O

-20°C

12352200