Ro 90-7501 [293762-45-5]

MedChem Express

Ro 90-7501 [293762-45-5]

10

293762-45-5

Research Use Only

99.10

C20H16N6

340.38

Ro 90-7501 is an amyloid beta42 (Abeta42) fibril assembly inhibitor that reduces Abeta42-induced cytotoxicity (EC50 of 2 microM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-beta gene expression and antiviral response[2]. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner[3]. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells[4].

NC1=CC=C2C(N=C(C3=CC=C4C(N=C(C5=CC=C(N)C=C5)N4)=C3)N2)=C1

-20°C,2°C to 8°C

12352200