RO1138452 [221529-58-4]

TargetMol Chemicals

RO1138452 [221529-58-4]

9

221529-58-4

Chemical

Research Use Only

RO1138452

99.34%

C19H23N3O

309.41

RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays [1].

3 years

CC(C)Oc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1

-20°C

12352200