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Ro5-3335 [30195-30-3]

Ro5-3335 [30195-30-3]

T4687
TargetMol Chemicals
CAS Number30195-30-3
DownloadMSDS
Product group Chemicals
Estimated Purity99.95%
Molecular Weight259.69
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Ro5-3335 [30195-30-3]
  • Delivery Days Customer
    9
  • CAS Number
    30195-30-3
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Ro5-3335
  • Estimated Purity
    99.95%
  • Molecular Formula
    C13H10ClN3O
  • Molecular Weight
    259.69
  • Scientific Description
    Ro5-3335 (CBFbeta-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 microM). Ro5-3335 represses RUNX1/CBFbeta-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFbeta. Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro.
  • Shelf life instruction
    3 years
  • SMILES
    Clc1ccc2NC(=O)CN=C(c3ccc[nH]3)c2c1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200