RO5068760 [947182-25-4]

TargetMol Chemicals

RO5068760 [947182-25-4]

86

Chemical

RO5068760

C28H27FIN3O6

647.43

RO5068760 , a substituted hydantoin, is a potent, highly selective, non-adenosine triphosphate (ATP)-competitive MEK1/2 inhibitors. RO5068760 shows significant efficacy in a broad spectrum of tumors with aberrant mitogen-activated protein kinase pathway activation. In vitro, RO5068760 demonstrates MEK1 kinase inhibitory activity with an IC50 of 0.025 microM in a cRaf/MEK/ERK cascade assay RO5068760 showed superior efficacy in tumors harboring B-RafV600E mutation.

3 years

[C@H]([C@@H](C)C1=CC=CC=C1)(C(NC2=C(F)C=C(I)C=C2)=O)N3C(=O)[C@H](NC3=O)C4=CC=C(OC[C@@H](CO)O)C=C4

-20°C

12352200