RO5101576 [1123155-95-2]

MedChem Express

RO5101576 [1123155-95-2]

9

1123155-95-2

Research Use Only

C36H38O8S

630.75

RO5101576 is a potent LTB4 receptor antagonist with activity to inhibit LTB4-induced calcium mobilization and chemotaxis of human neutrophils. RO5101576 significantly attenuated LTB4-induced pulmonary eosinophilia in guinea pigs. RO5101576 inhibited allergen- and ozone-induced pulmonary neutrophilia in nonhuman primates with efficacy comparable to that of budesonide. RO5101576 had no effect on LPS-induced neutrophilia in guinea pigs and cigarette smoke-induced neutrophilia in mice and rats. RO5101576 performed well in toxicology studies and was well tolerated[1].

O=C(CCCOC1=CC=CC(CCCCCCOC2=CC(C3=CSC=C3)=CC(C4=CC=C5OCOC5=C4)=C2)=C1CCC(O)=O)O

12352200