RO8994

AbMole BioScience

RO8994

9

1309684-94-3

Chemical

Research Use Only

C31H31Cl2FN4O4

613.51

RO8994 is a potent and selective spiroindolinone MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).

COC1=C(NC(=O)C2NC(CC(C)(C)C)C3(C2C4=C(F)C(=CC=C4)Cl)C(=O)NC5=C3C=CC(=C5)Cl)C=CC(=C1)C(N)=O

12352200