Western blot analysis of extracts from normal (control) and ROCK1 knockout (KO) HeLa cells using ROCK1 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts from normal (control) and ROCK1 knockout (KO) HeLa cells using ROCK1 Polyclonal Antibody at dilution of 1:1000.
ROCK1 Polyclonal Antibody
E-AB-62198
Product group Antibodies
Overview
- SupplierElabscience
- Product NameROCK1 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThis gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.
- UNSPSC12352203