ROCK1 Polyclonal Antibody
RD70331A
ApplicationsImmunoHistoChemistry
Product group Antibodies
ReactivityMouse, Rat
TargetRock1
Overview
- SupplierReddot Biotech
- Product NameROCK1 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration300 ug/ml
- ConjugateUnconjugated
- Gene ID19877
- Target nameRock1
- Target descriptionRho-associated coiled-coil containing protein kinase 1
- Target synonyms1110055K06Rik; p160 ROCK-1; p160ROCK; Rho-associated coiled-coil forming kinase 1; rho-associated protein kinase 1; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coiled-coil-containing protein kinase I; Roc; Rock-I
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
- ReactivityMouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203