Rofecoxib (Standard) [162011-90-7]

MedChem Express

Rofecoxib (Standard) [162011-90-7]

5

162011-90-7

Research Use Only

C17H14O4S

314.36

Rofecoxib (Standard) is the analytical standard of Rofecoxib. This product is intended for research and analytical applications. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 microM in U937 cells and > 15 microM in Chinese hamster ovary cells).

O=C1OCC(C2=CC=C(S(=O)(C)=O)C=C2)=C1C3=CC=CC=C3

41116135