Roflumilast [162401-32-3]

TargetMol Chemicals

Roflumilast [162401-32-3]

9

162401-32-3

Chemical

Research Use Only

Roflumilast

99.64%

C17H14Cl2F2N2O3

403.21

Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activities. Upon administration, roflumilast and its active metabolite roflumilast N-oxide selectively and competitively bind to and inhibit PDE4, which leads to an increase of both intracellular levels of cyclic-3, 5-adenosine monophosphate (cAMP) and cAMP-mediated signaling.

3 years

O(CC1CC1)C2=C(OC(F)F)C=CC(C(NC=3C(Cl)=CN=CC3Cl)=O)=C2

-20°C

12352200