Rolapitant [552292-08-7]

MedChem Express

Rolapitant [552292-08-7]

10

552292-08-7

Research Use Only

99.89

C25H26F6N2O2

500.48

Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model[1][2].

C[C@@](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)([H])OC[C@@]2(C3=CC=CC=C3)CC[C@@](CCC4=O)(N4)CN2

-20°C,2°C to 8°C

12352200