ROR alpha antibody [N2N3]
GTX100029
ApplicationsWestern Blot
Product group Antibodies
TargetRORA
Overview
- SupplierGeneTex
- Product NameROR alpha antibody [N2N3]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID6095
- Target nameRORA
- Target descriptionRAR related orphan receptor A
- Target synonymsIDDECA, NR1F1, ROR1, ROR2, ROR3, RORa1, RORalpha, RZR-ALPHA, RZRA, nuclear receptor ROR-alpha, RAR-related orphan nuclear receptor alpha, ROR-alpha, nuclear receptor RZR-alpha, nuclear receptor subfamily 1 group F member 1, retinoic acid receptor-related orphan receptor alpha, retinoid-related orphan receptor alpha, transcription factor RZR-alpha
- HostRabbit
- IsotypeIgG
- Protein IDP35398
- Protein NameNuclear receptor ROR-alpha
- Scientific DescriptionThe protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Beak JY, Kang HS, Huang W, et al. The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy. J Biol Chem. 2021,297(6):101358. doi: 10.1016/j.jbc.2021.101358Read this paper
- Luo J, Wang K, Yeh S, et al. LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling. Nat Commun. 2019,10(1):2571. doi: 10.1038/s41467-019-09784-9Read this paper
- Beak JY, Kang HS, Huang W, et al. The nuclear receptor RORα protects against angiotensin II-induced cardiac hypertrophy and heart failure. Am J Physiol Heart Circ Physiol. 2019,316(1):H186-H200. doi: 10.1152/ajpheart.00531.2018Read this paper
- Brożyna AA, Jóźwicki W, Skobowiat C, et al. RORα and RORγ expression inversely correlates with human melanoma progression. Oncotarget. 2016,7(39):63261-63282. doi: 10.18632/oncotarget.11211Read this paper
Datasheet
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