ROR1-IN-3

MedChem Express

ROR1-IN-3

999

Research Use Only

C36H32N6O3

596.68

ROR1-IN-3 (Compound 24d) is a potent and highly selective ROR1 kinase inhibitor (IC50 = 17.6 nM). ROR1-IN-3 demonstrates robust antitumor activity and inhibitory effect against ROR1 both in vitro and in vivo. ROR1-IN-3 has robust antiproliferative efficacy in vitro and in vivo. ROR1-IN-3 induces apoptosis in cancer cell lines. ROR1-IN-3 inhibits ROR1 downstream AKT/mTOR and NF-kappaB signaling pathway. ROR1-IN-3 can be studied in antitumor research[1].

CC1=C(C=C(C(NC2=CC=C3C(N(C=C3C4=CC=C(OC)N=C4)C)=C2)=O)C=C1)NC5=NC=CC(C6=CC=C(C=C6)OC7CC7)=N5

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