RORgamma antagonist 1

MedChem Express

RORgamma antagonist 1

14

Research Use Only

C35H60N2O2

540.86

RORgamma antagonist 1 (compound 22), a potent betulinic acid derivative, is an antagonist of RORgamma (KD=0.18 microM). RORgamma antagonist 1 exhibits anti-proliferative activity in HPAF-II pancreatic cancer xenograft model. RORgamma antagonist 1 inhibits RAS/MAPK and AKT/mTORC1 pathway, and induces caspase-dependent apoptosis in pancreatic cancer cells[1].

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12352200