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ProductsBack/Rosiglitazone . maleate [155141-29-0]
Chemical Structure
Chemical Structure
Chemical Structure

Rosiglitazone . maleate [155141-29-0]

Research Use Only
AG-CR1-3571
AdipoGen Life Sciences
CAS Number155141-29-0
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight357.4 . 116.1
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Rosiglitazone . maleate
  • Delivery Days Customer
    10
  • CAS Number
    155141-29-0
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C18H19N3O3S . C4H4O4
  • Molecular Weight
    357.4 . 116.1
  • Scientific Description
    Chemical. CAS: 155141-29-0. Formula: C18H19N3O3S . C4H4O4. MW: 357.4 . 116.1. Same activities as rosaglitazone (Prod. No. AG-CR1-3570) but different formulation. Antidiabetic, hypoglycemic agent. Potent and selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist. Potent insulin sensitizing agent binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Ameliorates insulin resistance. Improves blood pressure and vascular function. Enhances proliferation of endogenous neural progenitor cells (NPCs). Anti-inflammatory compound. Has controversial therapeutic effects on the cardiovascular system. Promotes adipocyte differentiation of mesenchymal stem cells (MSCs). - Same activities as rosaglitazone (Prod. No. AG-CR1-3570) but different formulation. Antidiabetic, hypoglycemic agent [1, 5]. Potent and selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist [2, 3]. Potent insulin sensitizing agent binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Ameliorates insulin resistance [4-6, 8]. Improves blood pressure and vascular function [7]. Enhances proliferation of endogenous neural progenitor cells (NPCs) [9]. Anti-inflammatory compound [10, 11]. Has controversial therapeutic effects on the cardiovascular system [12]. Promotes adipocyte differentiation of mesenchymal stem cells (MSCs) [13].
  • SMILES
    OC(=O)\C=C/C([O-])=O.C[NH+](CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C1=CC=CC=N1
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

References

  • [[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents: B.C. Cantello, et al.; J. Med. Chem. 37, 3977 (1994)
  • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPARgamma): J.M. Lehmann, et al.; J. Biol. Chem. 270, 12953 (1995)
  • Rosiglitazone: J.A. Balfour & G.L. Plosker; Drugs 57, 921 (1999) (Review)
  • Differential effects of insulin-sensitizers troglitazone and rosiglitazone on ion currents in rat vascular myocytes: G.A. Knock, et al.; Eur. J. Pharmacol. 368, 103 (1999)
  • Rosiglitazone: an agent from the thiazolidinedione class for the treatment of type 2 diabetes: A. Cheng-Lai & A. Levine; Heart Dis. 2, 326 (2000) (Review)
  • Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review: J.M. Malinowski & S. Bolesta; Clin. Ther. 22, 1151 (2000) (Review)
  • PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice: M.J. Ryan, et al.; Hypertension 3, 661 (2004)
  • Rosiglitazone: a review of its use in type 2 diabetes mellitus: E.D. Deeks & S.J. Keam; Drugs 67, 2747 (2007) (Review)
  • Rosiglitazone enhances the proliferation of neural progenitor cells and inhibits inflammation response after spinal cord injury: Q.Q. Meng, et al.; Neurosci. Lett. 503, 191 (2011)
  • Inhibitory effects of rosiglitazone on lipopolysaccharide-induced inflammation in a murine model and HK-2 cells: W.M. Wang, et al.; Am. J. Nephrol. 34, 152 (2011)