Rottlerin

MedChem Express

Rottlerin [82-08-6]

5

82-08-6

Research Use Only

98.39

C30H28O8

516.54

Rottlerin, a natural product purified from Mallotus Philippinensis , is a specific PKC inhibitor, with IC 50 values for PKCdelta of 3-6 microM, PKCalpha,beta,gamma of 30-42 microM, PKCepsilon,eta,aeta of 80-100 microM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation [1] [2] [3] . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection [4] [5] .

O=C(C1=C2C(C=CC(C)(C)O2)=C(O)C(CC3=C(O)C(C)=C(O)C(C(C)=O)=C3O)=C1O)/C=C/C4=CC=CC=C4

-20°C,2°C to 8°C

12352200