Roxindole (hydrochloride)

MedChem Express

Roxindole (hydrochloride) [108050-82-4]

5

108050-82-4

Research Use Only

99.53

C23H27ClN2O

382.93

Roxindole hydrochloride (EMD 38362), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors , with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT 1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT 1A (IC 50 =0.9 nM). Antipsychotic and antidepressant activities [1] [2] [3] .

OC1=CC2=C(C=C1)NC=C2CCCCN3CCC(C4=CC=CC=C4)=CC3.[H]Cl

-20°C

12352200