RP-6685 [2832047-80-8]

TargetMol Chemicals

RP-6685 [2832047-80-8]

9

Chemical

RP-6685

98.34%

C22H14F7N5O

497.37

RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Poltheta), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGreen assay, RP-6685 effectively hinders the enzymatic activity of Poltheta. In addition, it demonstrates significant antitumor efficacy as observed in a mouse tumor xenograft model [1].

3 years

Nc1ccc(nn1)C#CCN(C(=O)Cc1ncc(cc1C(F)(F)F)C(F)(F)F)c1ccc(F)cc1

-20°C

12352200