Overview
- SupplierGeneTex
- Product NameRPE65 antibody [N1C3]
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.4 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Annexin A5 regulates surface alphavbeta5 integrin for retinal clearance phagocytosis. Yu C et al., 2019 Oct 16, J Cell SciRead more
- Dietary antioxidants prevent age-related retinal pigment epithelium actin damage and blindness in mice lacking alphavbeta5 integrin. Yu CC et al., 2012 Feb 1, Free Radic Biol MedRead more
- Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina. Ruggiero L et al., 2012 May 22, Proc Natl Acad Sci U S ARead more
- Essential diurnal Rac1 activation during retinal phagocytosis requires alphavbeta5 integrin but not tyrosine kinases focal adhesion kinase or Mer tyrosine kinase. Mao Y et al., 2012 Mar, Mol Biol CellRead more
- Quantified F-Actin Morphology Is Predictive of Phagocytic Capacity of Stem Cell-Derived Retinal Pigment Epithelium. Mueller C et al., 2018 Mar 13, Stem Cell ReportsRead more
- Semaphorin4D-PlexinB1 Signaling Attenuates Photoreceptor Outer Segment Phagocytosis by Reducing Rac1 Activity of RPE Cells. Bulloj A et al., 2018 May, Mol NeurobiolRead more