RQ-00311651 [1257116-00-9]

MedChem Express

RQ-00311651 [1257116-00-9]

5

1257116-00-9

Research Use Only

C19H18F3N5O2

405.37

RQ-00311651 is a T-type calcium channel blocker that specifically targets the Cav3.2 isoform with a role in neuropathic and visceral pain. RQ-00311651 significantly inhibits T currents in HEK293 cells expressing human Cav3.1 or Cav3.2. RQ-00311651 also inhibited high potassium-induced calcium signaling. RQ-00311651 also inhibits antiallergic properties in rats and mice with neuropathic pain induced by spinal nerve injury or Paclitaxel (HY-B0015). Oral and intraperitoneal injection (10-20 mg/kg) inhibits Cerulein (HY-A0190)-induced acute pancreatitis and cyclophosphamide-induced cystitis in mice[1].

O=C(N[C@H](C)C1=NC=C(N=C1)OCC(F)(F)F)[C@@H]2[C@H](C2)C3=NC4=CC=CC=C4N3

12352200