RS 49676 [111962-89-1]

MedChem Express

RS 49676 [111962-89-1]

5

111962-89-1

Research Use Only

C25H28ClN3O5

485.96

RS 49676 is an N-substituted imidazole compound that exhibits strong in vitro activity against endogenous amoebae (ED50 < 0.1 ng/mL), but is ineffective against exogenous amoebae (epimastigotes). In vivo, RS 49676 (100 mg/kg/d, sc, 2 times) can prolong the average survival time of mice infected with Trypanosoma cruzi to more than 11 weeks.

ClC(C=C1)=CC=C1CC[C@@]2(O[C@H](CO2)COC3=CC=C(C=C3)NC(OCC)=O)CN4C=CN=C4

12352200