Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA644834DSR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA644834DSR1HU at dilution of 1:100
RSPO1 Antibody
CSB-PA644834DSR1HU
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetRSPO1
Overview
- SupplierCusabio
- Product NameRSPO1 Antibody
- Delivery Days Customer20
- ApplicationsELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID284654
- Target nameRSPO1
- Target descriptionR-spondin 1
- Target synonymsCRISTIN3; roof plate-specific spondin-1; RSPO; R-spondin homolog; R-spondin-1
- HostRabbit
- IsotypeIgG
- Protein IDQ2MKA7
- Protein NameR-spondin-1
- Scientific DescriptionActivator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203