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ProductsBack/RSPO1 Antibody

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA644834DSR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA644834DSR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA644834DSR1HU at dilution of 1:100

RSPO1 Antibody

CSB-PA644834DSR1HU

ApplicationsELISA, ImmunoHistoChemistry

Product group Antibodies

ReactivityHuman

TargetRSPO1

Overview

Supplier
Cusabio
Product Name
RSPO1 Antibody
Delivery Days Customer
20
Applications
ELISA, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID284654
Target name
RSPO1
Target description
R-spondin 1
Target synonyms
CRISTIN3, RSPO, R-spondin-1, R-spondin homolog, roof plate-specific spondin-1
Host
Rabbit
Isotype
IgG
Protein IDQ2MKA7
Protein Name
R-spondin-1
Scientific Description
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
Reactivity
Human
Storage Instruction
-20°C or -80°C
UNSPSC
41116161

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