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RSPO1/R-spondin-1, Human (CHO, His)

HY-P7114
MedChem Express
Protein IDQ2MKA7
Product group Proteins / Signaling Molecules
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Overview

  • Supplier
    MedChem Express
  • Product Name
    RSPO1/R-spondin-1, Human (CHO, His)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    98.0
  • Gene ID284654
  • Target name
    RSPO1
  • Target description
    R-spondin 1
  • Target synonyms
    CRISTIN3; roof plate-specific spondin-1; RSPO; R-spondin homolog; R-spondin-1
  • Protein IDQ2MKA7
  • Protein Name
    R-spondin-1
  • Scientific Description
    RSPO1/R-spondin-1 is a potent activator of the Wnt/beta-catenin signaling pathway and a secretory glycoprotein belonging to the R-spondin family. RSPO1 homotetramers synergize with LRP5/6 via LGR4/5/6 and activate the Wnt/beta-catenin pathway by inhibiting DKK1/Kremen-mediated LRP6 endocytosis. RSPO1 promotes beta-catenin nuclear translocation, drives HSC activation in liver fibrosis, inhibits adipocyte thermogenic gene expression, and promotes intestinal epithelial proliferation[1][2][3][4]. RSPO1/R-spondin-1 Protein, Human (CHO, His) is a recombinant human RSPO1 protein expressed in CHO cells with a C-6*His tag.
  • Storage Instruction
    -20°C
  • UNSPSC
    41116100