RU-SKI 43 (hydrochloride) [1782573-67-4]
HY-18366A
CAS Number1782573-67-4
Product group Chemicals
Estimated Purity99.55
Molecular Weight423.01
Overview
- SupplierMedChem Express
- Product NameRU-SKI 43 (hydrochloride) [1782573-67-4]
- Delivery Days Customer10
- CAS Number1782573-67-4
- CertificationResearch Use Only
- Estimated Purity99.55
- Molecular FormulaC22H31ClN2O2S
- Molecular Weight423.01
- Scientific DescriptionRU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity[1].
- SMILES[H]Cl.O=C(CNCC(C)CC)N1CCC2=C(C=CS2)C1COC3=CC=CC(C)=C3
- Storage Instruction2°C to 8°C
- UNSPSC12352200