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RU.521

HY-114180
MedChem Express
CAS Number2262452-06-0
DownloadMSDS
Product group Chemicals
Estimated Purity99.95
Molecular Weight415.23
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Overview

  • Supplier
    MedChem Express
  • Product Name
    RU.521 [2262452-06-0]
  • Delivery Days Customer
    10
  • CAS Number
    2262452-06-0
  • Certification
    Research Use Only
  • Estimated Purity
    99.95
  • Molecular Formula
    C19H12Cl2N4O3
  • Molecular Weight
    415.23
  • Scientific Description
    RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC 50 of 0.7 microM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutires syndrome (AGS) [1] .
  • SMILES
    O=C1OC(C2=C(O)N(C3=NC4=CC=C(Cl)C(Cl)=C4N3)N=C2C)C5=C1C=CC=C5
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200