
IHC image of CSB-PA856415LA01HU diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
RUBCN Antibody
CSB-PA856415LA01HU
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetRUBCN
Overview
- SupplierCusabio
- Product NameRUBCN Antibody
- Delivery Days Customer20
- ApplicationsELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID9711
- Target nameRUBCN
- Target descriptionrubicon autophagy regulator
- Target synonymsKIAA0226, RUBICON, SCAR15, run domain Beclin-1-interacting and cysteine-rich domain-containing protein, RUN and cysteine rich domain containing beclin 1 interacting protein, RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein, baron, beclin-1 associated RUN domain containing protein, rundataxin
- HostRabbit
- IsotypeIgG
- Protein IDQ92622
- Protein NameRun domain Beclin-1-interacting and cysteine-rich domain-containing protein
- Scientific DescriptionInhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC41116161

