Rucaparib-d8

MedChem Express

Rucaparib-d8

5

Research Use Only

C19H10D8FN3O

331.41

Rucaparib-d8 (AG014699-d8 ) is deuterium labeled Rucaparib. Rucaparib (AG014699) is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a Ki of 1.4 nM for PARP1. Rucaparib is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib has the potential for castration-resistant prostate cancer (CRPC) research[1][2][3][4].

O=C1NCCC2=C(C3=C([2H])C([2H])=C(C([2H])NC([2H])([2H])[2H])C([2H])=C3[2H])NC4=CC(F)=CC1=C42

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