Chemical Structure
Rugulosin [23537-16-8]
AG-CN2-0124
Overview
- SupplierAdipoGen Life Sciences
- Product NameRugulosin
- Delivery Days Customer10
- CAS Number23537-16-8
- CertificationResearch Use Only
- Estimated Purity>95%
- Hazard InformationWarning
- Molecular FormulaC30H22O10
- Molecular Weight542.5
- Scientific DescriptionAntibiotic [1]. Antibacteriophage. Antiviral [2]. Mycotoxin [3]. DNA replication, transcription and repair inhibitor [4]. Antibacterial [5]. RNA polymerase and ribonuclease H inhibitor [6]. Insecticidal. Cytotoxic [7]. HIV-1 integrase inhibitor [8]. Shows anti-MRSA (methicillin-resistant Staphylococcus aureus) activity [9]. Potential Hsp90 inhibitor through interacting with N-Hsp90 [10]. - Chemical. CAS: 23537-16-8. Formula: C30H22O10. MW: 542.5. Isolated from Penicillium sp. Antibiotic. Antibacteriophage. Antiviral. Mycotoxin. DNA replication, transcription and repair inhibitor. Antibacterial. RNA polymerase and ribonuclease H inhibitor. Insecticidal. Cytotoxic. HIV-1 integrase inhibitor. Shows anti-MRSA (methicillin-resistant Staphylococcus aureus) activity. Potential Hsp90 inhibitor through interacting with N-Hsp90.
- SMILESCC1=CC2=C(C(O)=C1)C(=O)C1=C(O)[C@H]3C(O)C4C5C(O)[C@H](C(O)=C6C(=O)C7=C(O)C=C(C)C=C7C(=O)C356)C14C2=O
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
References
- Studies in the biochemistry of micro-organisms. 95. Rugulosin, a crystalline colouring matter of Penicillium rugulosum Thom: J. Breen, et al.; Biochem. J. 60, 618 (1955)
- Inhibition of phage growth by an antibiotic rugulosin isolated from Myrothecium verucaria. I. Properties of the anti-phage effect: S. Nakamura, et al.; Jpn. J. Microbiol. 15, 113 (1971)
- Toxicological approach to (+) rugulosin, an anthraquinoid mycotoxin of Penicillium rugulosum Thom: Y. Ueno, et al.; Jpn. J. Exp. Med. 41, 177 (1971)
- Specific and non-specific interactions of two carcinogenic mycotoxins, luteoskyrin and rugulosin with nucleic acids: J.C. Bouhet, et al.; Ann. Nutr. Aliment. 31, 811 (1977)
- Mutagenicity and antibacterial activity of mycotoxins produced by Penicillium islandicum Sopp and Penicillium rugulosum: A.A. Stark, et al.; J. Environ. Pathol. Toxicol. 2, 313 (1978)
- Inhibitory effects of carcinogenic mycotoxins on deoxyribonucleic acid-dependent ribonucleic acid polymerase and ribonuclease H: F. Tashiro, et al.; Appl. Environ. Microbiol. 38, 191 (1979)
- Cytotoxicity against insect cells of entomopathogenic fungi of the genera Hypocrella (anamorph Aschersonia): possible agents for biological control: P. Watts, et al.; Mycol. Res. 107, 581 (2003)
- Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites: S.B. Singh, et al.; J. Ind. Microbiol. Biotechnol. 30, 721 (2003)
- New rugulosins, anti-MRSA antibiotics, produced by Penicillium radicum FKI-3765-2: H. Yamazaki, et al.; Org. Lett. 12, 1572 (2010)
- Inhibition and binding of Rugulosin with N-Hsp90: J.-J.Chen, et al.; Gaodeng Xuexiao Huaxue Xuebao 32, 88 (2011)