RV-1729 [1293915-42-0]

MedChem Express

RV-1729 [1293915-42-0]

5

1293915-42-0

Research Use Only

C39H39ClN8O5

735.23

RV-1729 is an inhibitor of the phosphatidylinositol 3-kinase-delta (PI3Kdelta). RV-1729 identifies inhibition of the PI3K isotype by quantifying the release of phosphatidylinositol 3,4, 5-triphosphate (PIP3) (IC50=12 nM), showing twice the selectivity for PI3Kdelta relative to PI3Kgamma. RV-1729 is also 16 times more selective to PI3Kalpha. RV-1729 regulates immune and inflammatory responses by inhibiting PI3Kdelta. RV-1729 can be used in studies of asthma and chronic obstructive pulmonary disease (COPD)[1].

O=C1N(CC2=CC=CC=C2Cl)C(CN3N=C(C4=CC=CC(O)=C4)C5=C(N)N=CN=C53)=NC6=C1C(C#CCCCC(N(CCOC)CCOC)=O)=CC=C6

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