RWJ-56110 dihydrochloride [2387505-58-8]

TargetMol Chemicals

RWJ-56110 dihydrochloride [2387505-58-8]

999

2387505-58-8

Research Use Only

RWJ-56110 dihydrochloride

C41H44Cl3F2N7O3

827.2

RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 microM), showing no effect on PAR-2, PAR-3, or PAR-4. It inhibits the aggregation of human platelets induced by SFLLRN-NH2 (IC50=0.16 microM) and thrombin (IC50=0.34 microM), with high selectivity relative to U46619. RWJ-56110 dihydrochloride also blocks angiogenesis and the formation of new vessels in vivo, and induces cell apoptosis[1][2].

3 years

Cl.Cl.NCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1)C(=O)NCc1ccccc1

-20°C

12352200