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RWJ52353 (hydrochloride)

HY-103216A
MedChem Express
CAS Number245744-13-2
DownloadMSDS
Product group Chemicals
Molecular Weight238.74
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Overview

  • Supplier
    MedChem Express
  • Product Name
    RWJ52353 (hydrochloride) [245744-13-2]
  • Delivery Days Customer
    5
  • CAS Number
    245744-13-2
  • Certification
    Research Use Only
  • Molecular Formula
    C11H11ClN2S
  • Molecular Weight
    238.74
  • Scientific Description
    RWJ-52353 hydrochloride is an orally potent, highly selective alpha2D adrenergic receptor agonist (Ki: 1.5 nM) with potential analgesic effects. RWJ-52353 hydrochloride demonstrated analgesic activity in abdominal tests in rats and mice, and improved agitation in mice in the hot plate test and tail flick test. RWJ-52353 hydrochloride also regulates the organic cation transporter ( OCT ) subtype, inhibiting rOCT1 and rOCT2 with IC 50 s of 100 microM and 20 microM respectively; it also activates rOCT3, affecting [3H]-1- in cells. Methyl-4-phenylpyridinium ([3H]MPP ) transport [1] [2] .
  • SMILES
    C1(C2=CCCC3=C2C=CS3)=CN=CN1.Cl
  • UNSPSC
    12352200