S 1360 [280571-30-4]

MedChem Express

S 1360 [280571-30-4]

5

280571-30-4

Research Use Only

C16H12FN3O3

313.28

S 1360 is a potent and selective inhibitor of HIV-1 integrase. S 1360 inhibits the catalytic activity of purified integrase ( IC50: 20 nM). The EC50, and CC50 of S 1360 in MTT assay (MT-4 cells infected with HIV-1 IIIB) are 200 nM and 12 microM, respectively. S 1360 has antiviral activity against both X4 tropic and R5 tropic strains, as well as NRTI, NNRTI and PI drug-resistant variants[1].

O=C(C1=CC=C(CC2=CC=C(C=C2)F)O1)/C=C(C3=NN=CN3)\O

12352200