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S 32212 hydrochloride

HY-103117
MedChem Express
CAS Number847871-78-7
DownloadMSDS
Product group Chemicals
Molecular Weight452.98
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Overview

  • Supplier
    MedChem Express
  • Product Name
    S 32212 hydrochloride [847871-78-7]
  • Delivery Days Customer
    5
  • CAS Number
    847871-78-7
  • Certification
    Research Use Only
  • Molecular Formula
    C25H29ClN4O2
  • Molecular Weight
    452.98
  • Scientific Description
    S 32212 hydrochloride is an inverse agonist of 5-HT receptors 5-HT2(CINI) and 5-HT2(CVSV) (Kis=6.6, 8.9 nM) and an antagonist of 5-HT2A and alpha2beta-adrenergic receptors (Ki=5.8, 5.8 nM). S 32212 hydrochloride can reduce the binding of GTPgammaS to Galphaq, and reduce the activity of phospholipase C (PLC) in HEK293 cells expressing 5-HT2(CINI) receptor and CHO cells expressing 5-HT2(CVSV) receptor ( EC 50 =38 and 18.6 nM, respectively). S 32212 hydrochloride (2.5 mg/kg) reduces 5-HT receptor agonist-induced head twitches and penile erections in mice and rats. S 32212 hydrochloride (10, 40 mg/kg) reduces immobility time in the forced swim test and marble burying behavior in mice and rats, exerting antidepressant and anxiolytic activities.
  • SMILES
    O=C(N1CCC2=C1C=CC3=CC=CC=C23)NC4=CC=C(OC)C(N5CCN(C)CC5)=C4.[H]Cl
  • UNSPSC
    12352200