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(S)-Crizotinib

HY-100549
MedChem Express
CAS Number1374356-45-2
Product group Chemicals
Estimated Purity99.81
Molecular Weight450.34
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Overview

  • Supplier
    MedChem Express
  • Product Name
    (S)-Crizotinib [1374356-45-2]
  • Delivery Days Customer
    10
  • CAS Number
    1374356-45-2
  • Estimated Purity
    99.81
  • Molecular Formula
    C21H22Cl2FN5O
  • Molecular Weight
    450.34
  • Scientific Description
    (S)-Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC 50 of 330 nM. (S)-Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumour growth in animal models [1] .
  • SMILES
    NC1=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@H](C4=C(Cl)C=CC(F)=C4Cl)C
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200