(S)-Crizotinib
HY-100549
CAS Number1374356-45-2
Product group Chemicals
Estimated Purity99.81
Molecular Weight450.34
Overview
- SupplierMedChem Express
- Product Name(S)-Crizotinib [1374356-45-2]
- Delivery Days Customer10
- CAS Number1374356-45-2
- Estimated Purity99.81
- Molecular FormulaC21H22Cl2FN5O
- Molecular Weight450.34
- Scientific Description(S)-Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC 50 of 330 nM. (S)-Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumour growth in animal models [1] .
- SMILESNC1=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@H](C4=C(Cl)C=CC(F)=C4Cl)C
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200