(S)-Sabutoclax [1228178-73-1]

MedChem Express

(S)-Sabutoclax [1228178-73-1]

5

1228178-73-1

Research Use Only

98.03

C42H40N2O8S

732.84

(S)-Sabutoclax ((S)-BI-97C1), an optically pure apogossypol derivative, is pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (S)-Sabutoclax (Compound II) inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1, and Bfl-1 with IC50 values of 0.31, 0.32, 0.20, and 0.62 microM, respectively. (S)-Sabutoclax also potently inhibits cell growth of human prostate cancer, lung cancer, and lymphoma cell lines with EC50 values of 0.13, 0.56, and 0.049 microM, respectively. (S)-Sabutoclax can be used for the research of apoptosis-based therapies against cancer[1].

O=C(C1=C(O)C(O)=CC2=C(O)[C@]([C@]3=C(C)C=C4C(C(NC[C@@H](C5=CC=CC=C5)C)=O)=C(O)C(O)=CC4=C3O)=C(C)C=C12)NC[C@@H](C6=CC=CC=C6)C

-20°C

12131703