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ProductsBack/S49076 HCl [1265965-19-2]

S49076 HCl [1265965-19-2]

Research Use Only
SYN-1217
SYNkinase
CAS Number1265965-19-2
Product group Chemicals
Estimated Purity>95%
Molecular Weight475
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Overview

  • Supplier
    SYNkinase
  • Product Name
    S49076 . HCl [1265965-19-2]
  • Delivery Days Customer
    10
  • CAS Number
    1265965-19-2
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Hazard Information
    Warning
  • Molecular Formula
    C22H23ClN4O4S
  • Molecular Weight
    475
  • Scientific Description
    Chemical. CAS: 1265965-19-2. Formula: C22H23ClN4O4S. MW: 475. S49076 is a novel, potent inhibitor of MET, AXL/MER and FGFR1/2/3. It can potently block cellular phosphorylation of MET, AXL and FGFRs and inhibit downstream signalling in vitro and in vivo. S49076 can inhibit the proliferation of MET- and FGFR2-dependent gastric cancer cells, block MET-driven migration of lung carcinoma cells, and inhibit colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. S49076 has also been shown to cause tumour growth arrest in bevacizumab-resistant tumours in xenograft models. - S49076 is a novel, potent inhibitor of MET, AXL/MER and FGFR1/2/3. It can potently block cellular phosphorylation of MET, AXL and FGFRs and inhibit downstream signalling in vitro and in vivo. S49076 can inhibit the proliferation of MET- and FGFR2-dependent gastric cancer cells, block MET-driven migration of lung carcinoma cells, and inhibit colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. S49076 has also been shown to cause tumour growth arrest in bevacizumab-resistant tumours in xenograft models.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200